118287-89-1 Usage
General Description
2-Chloro-4-diethoxymethyl-pyridine is a chemical compound that belongs to the pyridine family. It is a chlorinated derivative of pyridine and contains two diethoxymethyl groups. 2-Chloro-4-diethoxymethyl-pyridine is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is commonly used as a building block in the production of various drugs and agricultural chemicals. It is important to handle this compound with care, as it is toxic and can be harmful if ingested or inhaled. Proper precautions should be taken when handling and storing 2-Chloro-4-diethoxymethyl-pyridine to ensure the safety of those working with it.
Check Digit Verification of cas no
The CAS Registry Mumber 118287-89-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,8 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 118287-89:
(8*1)+(7*1)+(6*8)+(5*2)+(4*8)+(3*7)+(2*8)+(1*9)=151
151 % 10 = 1
So 118287-89-1 is a valid CAS Registry Number.
118287-89-1Relevant articles and documents
Synthesis of protected 5-formylpyrido[2,3-d] pyrimidine via a 2,3,4-trisubstituted pyridine using an ortho-litmation strategy; applicationtothe synthesis of a folate derivative
Watson, Samuel E.,Markovich, Anatoly
, p. 2149 - 2155 (1998)
A convenient route for the preparation of a protected 5-formylpyrido[2,3-d]pyrimidine from 2,3,4-trisubstituted pyridines has been developed. The readily available diethylacetal of pyridinc 4-carboxaldehyde is chlorinated at the 2-position and then treated with LDA and methyl chloroformate to give a 2,3,4-trisubstituted pyridine (12). Treatment of 12 with guanidine hydrochloride gives the pyrido[23-rf]pyrimidine in good yield. A 4-aminobenzoylglutamic acid side chain is installed by means of a reductive amination step to provide a 5-substituted derivative that is, after deprotection, a confonnationally unrestricted analog of 5,10-methylenetetrahydrofolate(1), the natural co-factor for thymidylate synthase, an important chemotherapeutic target in the treatment of cancer.
