118344-75-5

Basic information

• Product Name: 2,4-Pyrimidinediamine, 6-ethyl-5-[3-nitro-4-[(2-phenylethyl)amino]phenyl]-
• CAS NO: 118344-75-5
• Molecular Formula: C20H22N6O2
• Molecular Weight: 378.434
• Mol File: 118344-75-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-Pyrimidinediamine, 6-ethyl-5-[3-nitro-4-[(2-phenylethyl)amino]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrimidinediamine, 6-ethyl-5-[3-nitro-4-[(2-phenylethyl)amino]phenyl]-(118344-75-5)
• EPA Substance Registry System: 2,4-Pyrimidinediamine, 6-ethyl-5-[3-nitro-4-[(2-phenylethyl)amino]phenyl]-(118344-75-5)

Safety Data

• Hazardous Substances Data: 118344-75-5(Hazardous Substances Data)

Upstream product

• 64-04-0 phenethylamine 
• 21813-35-4 2,4-diamino-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine 

Relevant articles and documents

Antifolate agents

2,4-Diamino-5-phenylpyrimidines in the form of the free base or an acid addition salt thereof are provided having the structural formula (I): STR1 wherein R1 is an alkoxy, aralkoxy or a mono-substituted or disubstituted amino group, R2 is a nitro group, and R3 is an alkyl group. The compounds act as antifolate agents and are useful for therapeutic treatment, for example as antitumour agents, antipsoriatic agents, antibacterial agents, antitrypanosomal agents and antimalarial agents. Pharmaceutical preparations comprising these compounds for administration to mammals, and methods for preparing the compounds, are disclosed. Particularly useful new compounds, especially for antitumour therapy, have the structural formula IA: STR2 in which formula IA: n is 1-6; R1 represents hydrogen or alkyl; R4, R5 and R6, which may be identical or different, each represnt hydrogen, alkyl, alkoxy, halo, nitro, perfluoroalkyl, a group of formula --CO2 Ra wherein Ra represents hydrogen, alkyl or alkoxyalkyl, or a group of formula --COBRb Rc wherein Rb and Rc which may be identical or different each represent alkyl; and R3 represents alkyl.