118353-34-7

Basic information

• Product Name: CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
• Synonyms: RP-CTP-ALPHA-S SODIUM SALT;SP-CTP-ALPHA-S SODIUM SALT;CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT;CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;cytidine-5’-o-(1-thiotriphosphate),sp-isomer(sp-ctp-alpha-s),sodiumsalt;Cytidine, 5'-P''-ester with [P''(S)]-thiotriphosphoric acid
• CAS NO: 118353-34-7
• Molecular Formula: C9H12N3Na4O13P3S
• Molecular Weight: 587.15
• Mol File: 118353-34-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(118353-34-7)
• EPA Substance Registry System: CYTIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT(118353-34-7)

Safety Data

• Hazardous Substances Data: 118353-34-7(Hazardous Substances Data)

Upstream product

• 16628-82-3 2',3'-O-(methoxymethylidene)cytidine 
• 118275-96-0 C₁₁H₁₄N₃O₁₃P₃S^(2-) 

Relevant articles and documents

Rapid and Efficient Synthesis of Nucleoside 5'-O-(1-Thiotriphosphates), 5'-Triphosphates and 2',3'-Cyclophosphorothioates Using 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one phosphitylates the 5'-hydroxy group of a nucleoside to form an intermediate (2), which on subsequent reaction with pyrophosphate produces, in a double displacement process, a P2,P3-dioxo-P1-5'-nucleosidylcyclotriphophite (3).Oxidation with sulfur gives a nucleoside 5'-(1-thiocyclotriphosphate) (4), which is hydrolyzed to the diastereomeric mixture of a nucleoside 5'-O-(1-thiotriphosphate) (5).Alternatively, 3 can be oxidized with iodine/water to furnish nucleoside 5'-triphosphates 6.This reagent can also be applied to the synthesis of nucleoside 2',3'-cyclic phosphorothioates.Protection of nucleobase functional groups is not required.