118362-74-6

Basic information

• Product Name: 3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile
• Synonyms: 3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile
• CAS NO: 118362-74-6
• Molecular Weight: 203.241
• Mol File: 118362-74-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile(118362-74-6)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile(118362-74-6)

Safety Data

• Hazardous Substances Data: 118362-74-6(Hazardous Substances Data)

Upstream product

• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 36025-15-7 2-bromo-1-(4-methoxyphenyl)-2-methylpropan-1-one 
• 2040-20-2 4-methoxyisobutyrophenone 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 74-88-4 methyl iodide 
• 7321-55-3 2,2-dimethylmalononitrile 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant articles and documents

Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles

A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using commercially available substrates. The method is expected to show further utility in future synthetic procedures.

Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center

A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.

MESOMERIC ANIONS. X. METHYLATION OF ALKALI-METAL DERIVATIVES OF SOME 1,3-KETONITRILES

The effect of polar factors on the relative nucleophilicity of the oxygen and carbon reaction centers in the alkali-metal derivatives of 2-(X-benzoyl)acetonitriles, 2-(X-benzoyl)propionitriles, and 2-(X-phenyl)acetylacetonitriles was investigated.During methylation with methyl iodide and methyl p-toluenesulfonate in DMFA the ratio of the C- and O-methylation products for all the investigated compounds decreases with increase in the accepting power of the substituent X.It was shown that the sensitivity of the C-reaction center to the effect of the substituent X is greater than that of the O-center.