118383-65-6

Basic information

• Product Name: 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid
• Synonyms: 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid
• CAS NO: 118383-65-6
• Molecular Weight: 290.07
• Mol File: 118383-65-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid(118383-65-6)
• EPA Substance Registry System: 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid(118383-65-6)

Safety Data

• Hazardous Substances Data: 118383-65-6(Hazardous Substances Data)

Upstream product

• 621-44-3 3-nitro-L-tyrosine 

Downstream Products

• 118383-66-7 5-(4-hydroxy-3-nitrobenzyl)-2-imino-4-oxothiazolidine 
• 118383-51-0 5-(3-amino-4-hydroxybenzyl)-2,4-thiazolidinedione 
• 1027049-96-2 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-phenyl-acetamide 
• 1026496-60-5 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide 
• 1025992-21-5 3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide 
• 1027423-24-0 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-fluoro-phenyl)-acetamide 
• 1027037-44-0 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(2-methyl-thiazol-4-yl)-acetamide 
• 118384-29-5 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(benzoyl)benzoxazole 
• 118383-42-9 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-(4-aminobenzyl)benzoxazole 
• 1026364-42-0 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide 
• 1026469-13-5 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(5-ethyl-pyridin-2-yl)-acetamide 
• 118383-57-6 N-[5-(2,4-dioxothiazolidin-5-yl)methyl-2-hydroxyphenyl]-2-(4-dimethylaminophenyl)acetamide 

Relevant articles and documents

Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships

A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2,4-thiazolidinediones was also established using aminophenol 2,4- thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.

Benzoxazole derivatives

Novel benzoxazole derivative of the formula: STR1 wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group STR2 is a group of the formula: --CH2 -- or --CH=, and a pharmaceutically aceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.