118397-70-9

Basic information

• Product Name: α-peltatin 5-succinate
• Synonyms: α-peltatin 5-succinate
• CAS NO: 118397-70-9
• Molecular Weight: 500.459
• Mol File: 118397-70-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-peltatin 5-succinate(CAS DataBase Reference)
• NIST Chemistry Reference: α-peltatin 5-succinate(118397-70-9)
• EPA Substance Registry System: α-peltatin 5-succinate(118397-70-9)

Safety Data

• Hazardous Substances Data: 118397-70-9(Hazardous Substances Data)

Upstream product

• 568-53-6 (5R,5aR,8aR)-10-Hydroxy-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 118356-14-2 4'-carbobenzoxy-α-peltatin 

Relevant articles and documents

Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and α-peltatin

A principal mechanism of action of the clinical antitumor drugs etoposide (1) and teniposide (2) is the inhibition of catalytic activity of type II DNA topoisomerase and concurrent enzyme-mediated production of lethal DNA strand breaks. Substitution of the glycosidic moiety of 1 or 2 by ester and ethers, as well as the esterification and etherification of α-peltatin (4) including its glucosidic ethylidene and thenylidene cyclic acetals (25 and 26), has afforded compounds of much less activity than that of 1. The in vitro cytotoxicity (KB) appears to have no correlation with the inhibitory activity of the human DNA topoisomerase II.