118409-57-7 Usage
Description
AG 18 is a specific inhibitor for the epidermal growth factor receptor (EGFR), which is a protein that plays a crucial role in cell growth and division. It is a yellow powder that effectively inhibits EGFR with an IC50 of 35 μM, making it a valuable compound in the field of cancer research and treatment.
Uses
Used in Pharmaceutical Industry:
AG 18 is used as an inhibitor for the epidermal growth factor receptor (EGFR) for its ability to inhibit EGF-dependent cell proliferation. This makes it a potential candidate for the development of targeted cancer therapies, particularly for tumors that overexpress EGFR.
Used in Cancer Research:
AG 18 is used as a research tool to study the role of EGFR in cancer cell growth and proliferation. Its specificity and potency in inhibiting EGFR make it a valuable compound for understanding the underlying mechanisms of cancer development and progression.
Used in Drug Development:
AG 18 is used as a starting point for the development of new drugs targeting EGFR-mediated signaling pathways. Its chemical properties and inhibitory activity can be further optimized to improve its efficacy, selectivity, and pharmacokinetic properties, potentially leading to the development of more effective cancer treatments.
Used in Drug Delivery Systems:
AG 18 can be incorporated into various drug delivery systems, such as nanoparticles or liposomes, to improve its bioavailability, targeting, and therapeutic outcomes. These systems can help overcome limitations in drug solubility, stability, and delivery, ultimately enhancing the effectiveness of AG 18 in cancer treatment.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Check Digit Verification of cas no
The CAS Registry Mumber 118409-57-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,4,0 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 118409-57:
(8*1)+(7*1)+(6*8)+(5*4)+(4*0)+(3*9)+(2*5)+(1*7)=127
127 % 10 = 7
So 118409-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
118409-57-7Relevant articles and documents
Synthesis of Polyfunctionalized Pyrroles via Green Chemical Methods
Pagadala, Ramakanth,Anugu, Sreenivasa
, p. 181 - 186 (2018)
Water was found to be an excellent solvent for the one-pot synthesis of tetrasubstituted pyrrole derivatives under ultrasound involving the standard Knoevenagel condensation followed by the Michael type reaction. A new catalyst free system, excellent atom
Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids
Muhammad, Shoaib,Javed, Muhammad Naveed,Ali, Firdous Imran,Bari, Ahmed,Hashmi, Imran Ali
, (2020/01/21)
Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.
Solvatochromism of catechol derivatives - Solute/solvent interactions
Riedel, Franziska,Spange, Stefan
, p. 1261 - 1268 (2013/08/24)
The solvatochromism of nine push-pull substituted catechol derivatives has been studied in a set of 39 various solvents. The influence of successive methyl substitution at the catechol OH groups on the extent of the solvatochromic shift has been investiga