1184175-04-9

Basic information

• Product Name: tert-butyl (S)-3-((3-(6-isopropoxypyridin-3-yl)-1-trityl-1H-indazol-5-yl)carbamoyl)-3-(methylthio)pyrrolidine-1-carboxylate
• Synonyms: tert-butyl (S)-3-((3-(6-isopropoxypyridin-3-yl)-1-trityl-1H-indazol-5-yl)carbamoyl)-3-(methylthio)pyrrolidine-1-carboxylate
• CAS NO: 1184175-04-9
• Molecular Weight: 753.965
• Mol File: 1184175-04-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-3-((3-(6-isopropoxypyridin-3-yl)-1-trityl-1H-indazol-5-yl)carbamoyl)-3-(methylthio)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-3-((3-(6-isopropoxypyridin-3-yl)-1-trityl-1H-indazol-5-yl)carbamoyl)-3-(methylthio)pyrrolidine-1-carboxylate(1184175-04-9)
• EPA Substance Registry System: tert-butyl (S)-3-((3-(6-isopropoxypyridin-3-yl)-1-trityl-1H-indazol-5-yl)carbamoyl)-3-(methylthio)pyrrolidine-1-carboxylate(1184175-04-9)

Safety Data

• Hazardous Substances Data: 1184175-04-9(Hazardous Substances Data)

Upstream product

• 122684-33-7 methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 
• 942190-28-5 1-(tert-butyl) 3-methyl 3-(methylthio)pyrrolidine-1,3-dicarboxylate 
• 1093063-61-6 methyl (S)-3-(methylthio)pyrrolidine-3-carboxylate 
• 1093063-63-8 1-(tert-butyl) 3-methyl (S)-3-(methylthio)pyrrolidine-1,3-dicarboxylate 
• 871839-91-7 2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 1184174-14-8 3-(6-isopropoxypyridin-3-yl)-5-nitro-1-trityl-1H-indazole 
• 870521-31-6 5-bromo-2-isopropoxy-pyridine 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 942189-39-1 3-bromo-5-nitro-1-trityl-1H-indazole 
• 76-83-5 trityl chloride 
• 5401-94-5 5-nitroindazole 
• 1093063-62-7 (S)-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester L-tartrate 
• 1184174-33-1 1-benzyl-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 1184173-73-6 (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide 

Relevant articles and documents

PYRROLIDINYL-BASED COMPOUNDS

Disclosed herein are pyrrolidinyl-based compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

PROCESS FOR PREPARING SPRAY DRIED SOLID DISPERSIONS OF (S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3- (METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE FOR PHARMACEUTICAL PREPARATIONS

A process for preparing spray dried solid dispersions of (S)-N-(3-(6- isopropoxypyridin-3-yl)-lH4ndazol-5-yl)-l-(2-(4-(4-(l-methyl-lH-l,2,4-triazol-3-yl)phenyl)- 3,6-dihydropyridin-l(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous free base and hypromellose acetate succinate for pharmaceutical preparations including pharmaceutical capsule preparations.

(S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS

The invention includes a granular composition comprising the active ingredient (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide, wherein a total amount of active ingredient comprises by weight % about 60-90% (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-y1)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide Form 1 HCl, about 10-30% (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous HCl, and about 0-5% (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous free base.