118425-61-9

Basic information

• Product Name: (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine
• Synonyms: (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine
• CAS NO: 118425-61-9
• Molecular Weight: 299.37
• Mol File: 118425-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine(118425-61-9)
• EPA Substance Registry System: (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine(118425-61-9)

Safety Data

• Hazardous Substances Data: 118425-61-9(Hazardous Substances Data)

Upstream product

• 1395084-65-7 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 

Relevant articles and documents

A new class of selective and potent 7-dehydrocholesterol reductase inhibitors

We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells. In the latter assay panel, several of the compounds were distinguished by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of cholesterol biosynthesis. In a whole-cell assay, the most active compound 5f showed a much stronger inhibition of overall cholesterol biosynthesis (IC 50 2.3 nM) than BM 15.766 (IC50 500 nM), presently the most selective known inhibitor of 7-DHCR. Since a defect of 7-dehydrocholesterol reductase is associated with Smith-Lemli-Opitz syndrome (SLOS), the potent and selective inhibitors reported here will enable more detailed investigation of the pathogenesis of SLOS.