118430-73-2

Basic information

• Product Name: 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE
• Synonyms: 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE;3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-AMINE;BUTTPARK 30\09-76;5-Amino-3-tert-butyl-1-methylpyrazole,97%;5-Amino-3-(tert-butyl)-1-methyl-1H-pyrazole;5-amino-3-tert-butyl-1-methylpyrazole 97% 4g;5-AMINO-3-TETR-BUTYL-1-METHYLPYRAZOLE;5-Amino-3-t-butyl-1-methylpyrazole
• CAS NO: 118430-73-2
• Molecular Formula: C₈H₁₅N₃
• Molecular Weight: 153.22
• EINECS: 604-604-1
• Mol File: 118430-73-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 266.666 °C at 760 mmHg
• Flash Point: 115.076 °C
• Appearance: /
• Density: 1.043 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.69±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE(118430-73-2)
• EPA Substance Registry System: 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE(118430-73-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 118430-73-2(Hazardous Substances Data)

Usage

General Description

5-Amino-3-tert-butyl-1-methylpyrazole is a chemical compound with the molecular formula C8H14N4. It is a pyrazole derivative that contains an amino group and a tert-butyl group. 5-AMINO-3-TERT-BUTYL-1-METHYLPYRAZOLE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known for its ability to inhibit the activity of certain enzymes, making it a potential candidate for drug development. Additionally, it is used as a building block for the synthesis of various organic compounds. Overall, 5-amino-3-tert-butyl-1-methylpyrazole has a wide range of applications in the field of chemical and pharmaceutical research.

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 60-34-4 methylhydrazine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 29586-83-2 (2Z)-3-chloro-4,4-dimethylpent-2-enenitrile 
• 302-15-8 methylhydrazine sulfuric acid 
• 32064-64-5 methylhydrazine oxalic acid salt 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 

Downstream Products

• 403608-38-8 5,6,7,8-tetrafluoro-3-tert-butyl-1-methyl-1H-pyrazolo[3,4-b]quinoline 
• 1027509-13-2 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 1027831-91-9 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 
• 1026971-98-1 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 851520-56-4 3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 857266-62-7 phenyl (3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)carbamate 
• 857266-35-4 N-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-N'-{3-[(2-chloropyrimidin-5-yl)ethynyl]phenyl}urea 
• 857287-55-9 N-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-N'-(3-ethynylphenyl)urea 
• 756839-38-0 1-(2-Aminobenzyl)-3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-urea 
• 1104803-47-5 4-(3-Tert-butyl-1-methyl-1H-pyrazol-5-ylamino)-N-(thiazol-2-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor.

Inhibitors of the MAP kinase p38 provide a novel approach for the treatment of osteoporosis, inflammatory disorders, and cancer. We have identified N-(3-tert-butyl-1-methyl-5-pyrazolyl)-N'-(4-(4-pyridinylmethyl)phenyl)urea as a potent and selective p38 ki

Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

A series of 1-substituted 3-(t-butyl/trifluoromethyl)pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for hTRPV1 antagonism. The structure activity relationship indicated that the 3-chlorophenyl group at the 1-position of pyrazole was the optimized hydrophobic group for antagonistic potency and the activity was stereospecific to the S-configuration, providing exceptionally potent antagonists 13S and 16S with Ki(CAP) = 0.1 nM. Particularly significant, 13S exhibited antagonism selective for capsaicin and NADA and not for low pH or elevated temperature. Both compounds also proved to be very potent antagonists for rTRPV1, blocking in vivo the hypothermic action of capsaicin, consistent with their in vitro mechanism. The docking study of compounds 13S and 16S in our hTRPV1 homology model indicated that the binding modes differed somewhat, with that of 13S more closely resembling that of GRT12360.

Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme

The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with favorable drug-like properties. γ-Secretase modulator 28 displayed good activity for in vitro inhibition of Aβ42, as well as substantial improvement in ADME and physicochemical properties, including aqueous solubility. Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.