1184935-24-7

Basic information

• Product Name: 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
• Synonyms: 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
• CAS NO: 1184935-24-7
• Molecular Weight: 269.693
• Mol File: 1184935-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(1184935-24-7)
• EPA Substance Registry System: 3-amino-6-chloro-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile(1184935-24-7)

Safety Data

• Hazardous Substances Data: 1184935-24-7(Hazardous Substances Data)

Upstream product

• 1086-02-8 2,6-dichloro-4-phenylpyridine-3,5-dicarbonitrile 

Downstream Products

• 1184935-25-8 3-amino-6-morpholin-4-yl-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 

Relevant articles and documents

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.