118509-98-1

Basic information

• Product Name: (E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate
• Synonyms: (E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate
• CAS NO: 118509-98-1
• Molecular Weight: 237.212
• Mol File: 118509-98-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate(118509-98-1)
• EPA Substance Registry System: (E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate(118509-98-1)

Safety Data

• Hazardous Substances Data: 118509-98-1(Hazardous Substances Data)

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 56926-73-9 trans-3-(3-nitro-4-hydroxyphenyl)-acrylic acid 
• 56428-73-0 3-(4-hydroxy-3-nitrophenyl)-2-propenoic acid methyl ester 
• 74-88-4 methyl iodide 
• 50651-39-3 2-nitro-4-acetylamino-anisole 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 31680-08-7 4-methoxy-3-nitrobenzaldehyde 
• 67-56-1 methanol 
• 58435-22-6 (E)-3-(4-methoxy-3-nitrophenyl)acrylic acid 

Downstream Products

• 1356017-29-2 methyl (E)-3-(3-amino-4-methoxyphenyl)acrylate 
• 1356016-37-9 (E)-3-(3-amino-4-methoxy-phenyl)-prop-2-en-1-ol 
• 875230-36-7 3-(3-amino-4-methoxy-phenyl)-propan-1-ol 
• 1356015-56-9 pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide 

Relevant articles and documents

4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads

Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biological evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Additionally, 61 was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Cerium(IV)-induced nitration of cinnamic acids. Novel remote electrophilic substitution

The treatment of (E)-3,4-dimethoxycinnamic acid with ceric amonium nitrate in trifluoroacetic acid afforded (E)1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene in 79percent yield.The unusual ipso substitution of the carboxylic acid moiety by a nitro functional center illustrated a new reaction manifold of cerium(IV).Six cinnamic acids were examined to ascertain the generality of the transformation.The bidentate nitrato structure of the metal salt is believed to account for the nitrating ability of this system.