118521-01-0

Basic information

• Product Name: 5-cyano-2-(2',4'-dioxopentan-3'-ylthio)-6-phenyl-3,4-dihydropyrimidin-4-one
• CAS NO: 118521-01-0
• Molecular Weight: 327.364
• Mol File: 118521-01-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-cyano-2-(2',4'-dioxopentan-3'-ylthio)-6-phenyl-3,4-dihydropyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyano-2-(2',4'-dioxopentan-3'-ylthio)-6-phenyl-3,4-dihydropyrimidin-4-one(118521-01-0)
• EPA Substance Registry System: 5-cyano-2-(2',4'-dioxopentan-3'-ylthio)-6-phenyl-3,4-dihydropyrimidin-4-one(118521-01-0)

Safety Data

• Hazardous Substances Data: 118521-01-0(Hazardous Substances Data)

Upstream product

• 1694-29-7 3-chloropentane-2,4-dione 
• 70638-52-7 5-cyano-6-phenyl-2-thiouracil 

Downstream Products

• 118521-09-8 2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide 
• 118521-08-7 2-acetyl-6-carboxamido-5H-3-methyl-7-phenylthiazolo<3,2-a>pyrimidin-5-one 

Relevant articles and documents

NEW PYRIDINE DERIVATIVES: SYNTHESIS AND APPLICATION OF THIAZOLO-TRIAZOLO-PYRIMIDINE AS BACTERICIDES, FUNGICIDES AND BIOREGULATORS

5-Cyano-4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (IIa-g); and with chloroacetic acid ethyl chloroacetate to give compounds III and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g).The parent thiazolopyrimidine (VI) was prepared from compound III by refluxing with acetic anhydride.Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo pyrimidine derivatives.The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure.Key words: Pyrimidinethione; thiazolopyrimidine; triazolopyrimidine; synthesis and reactions; biological activity.