1185262-55-8

Basic information

• Product Name: C₂₀H₂₆O₄Si
• Synonyms: C₂₀H₂₆O₄Si
• CAS NO: 1185262-55-8
• Molecular Weight: 358.51
• Mol File: 1185262-55-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₆O₄Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₆O₄Si(1185262-55-8)
• EPA Substance Registry System: C₂₀H₂₆O₄Si(1185262-55-8)

Safety Data

• Hazardous Substances Data: 1185262-55-8(Hazardous Substances Data)

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 7677-24-9 trimethylsilyl cyanide 

Relevant articles and documents

Lanthanum tricyanide-catalyzed acyl silane-ketone benzoin additions and kinetic resolution of resultant α-silyloxyketones

We report the full account of our efforts on the lanthanum tricyanide-catalyzed acyl silane-ketone benzoin reaction. The reaction exhibits a wide scope in both acyl silane (aryl, alkyl) and ketone (aryl-alkyl, alkyl-alkyl, aryl-aryl, alkenyl-alkyl, alkynyl-alkyl) coupling partners. The diastereoselectivity of the reaction has been examined in both cyclic and acyclic systems. Cyclohexanones give products arising from equatorial attack by the acyl silane. The diastereoselectivity of acyl silane addition to acyclic α-hydroxy ketones can be controlled by varying the protecting group to obtain either Felkin-Ahn or chelation control. The resultant α-silyloxyketone products can be resolved with selectivity factors from 10 to 15 by subjecting racemic ketone benzoin products to CBS reduction.