118539-51-8

Basic information

• Product Name: (Z)-3-Cyclobutylamino-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester
• CAS NO: 118539-51-8
• Molecular Weight: 360.212
• Mol File: 118539-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-3-Cyclobutylamino-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-Cyclobutylamino-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester(118539-51-8)
• EPA Substance Registry System: (Z)-3-Cyclobutylamino-2-(2,4-dichloro-5-fluoro-benzoyl)-acrylic acid ethyl ester(118539-51-8)

Safety Data

• Hazardous Substances Data: 118539-51-8(Hazardous Substances Data)

Upstream product

• 2516-34-9 cyclobutylamine 
• 86483-52-5 2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester 

Relevant articles and documents

Fluoronaphthyridines and Quinolones as Antibacterial Agents. 1. Synthesis and Structure-Activity Relationships of New 1-Substituted Derivatives

A series of novel 7-piperazinyl-1-substituted-6-fluoroquinolones and naphthyridines have been prepared and their antibacterial activities evaluated.These derivatives are characterized by having alkyl, alkenyl, arylalkyl, cycloalkyl, and cycloalkenyl groups at the 1-position.As a result of this study, derivatives 7 and 26, which are substituted with tert-butyl groups at N-1, were found to possess excellent in vitro and in vivo potency, particularly against Staphylococcus aureus, comparable to that of norfloxacin (1) or ciprofloxacin (10).Structure-activity relationships of N-1 substituted alkyls and cycloalkyls are also discussed.