118559-28-7Relevant articles and documents
An efficient synthesis of cyanoarenes and cyanoheteroarenes via lithiation followed by electrophilic cyanation
Sato, Nobuhiro,Yue, Qi
, p. 5831 - 5836 (2003)
A one-pot procedure for the conversion of mono-substituted arenes and heteroarenes into the ortho-cyano derivatives was achieved through directed lithiation followed by electrophilic cyanation with phenyl cyanate. This reaction method proved to be applicable to halogen-lithium exchanged intermediates, so especially useful for the synthesis of benzonitriles. The scope of the reaction sequence was explored using a number of substrates.
Selective functionalization of cyano-phenyl-2-oxazolines using TMPMgCl·LiCl
Bozzini, Leandro A.,Batista, Jo?o H.C.,de Mello, Murilo B.M.,Vessecchi, Ricardo,Clososki, Giuliano C.
, p. 4186 - 4190 (2017)
Metalated phenyl-2-oxazolines bearing cyano groups can be selectively obtained through the reaction of TMPMgCl·LiCl with the appropriate substrate. Subsequent reaction with different electrophiles furnished the functionalized derivatives in good yields. D
Palladium-Catalyzed Coupling of Oxazol-2-yl and 2-Oxazolin-2-yltrimethylstannanes with Aromatic Halides. A New Entry to 2-Aryl and 2-Heteroaryl Oxazoles and Oxazolines
Dondoni, Alessandro,Fantin, Giancarlo,Fogagnolo, Marco,Medici, Alessandro,Pedrini, Paola
, p. 693 - 696 (2007/10/02)
4-Methyloxazole and 4,4-dimethyl-2-oxazoline were treated with n-butyllithium and trimethyltin chloride to give the corresponding 2-trimethylstannyl derivatives which in the presence of tetrakis(triphenylphosphine)palladium(0) as a catalyst undergo cross-
