1185908-30-8 Usage
Description
(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is a hydrazine derivative featuring a thioamide functional group. It is recognized for its potential biological activities, such as antimicrobial and antitumor properties, and is widely utilized in organic synthesis and pharmaceutical research. (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide's chemical structure comprises a phenyl group connected to a hydrazine and thioamide moiety, with a hydroxybenzylidene group linked to the hydrazine nitrogen in an E-configuration. This unique structure endows the chemical with a broad spectrum of potential applications across the fields of medicine, pharmacology, and biochemistry.
Uses
Used in Pharmaceutical Research:
(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its versatile chemical structure and potential biological activities.
Used in Antimicrobial Applications:
In the medical field, (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is used as an antimicrobial agent for its ability to combat a range of microorganisms, including bacteria and fungi, making it a valuable asset in the development of new antibiotics and antifungal medications.
Used in Antitumor Applications:
(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is used as an antitumor agent, leveraging its potential to inhibit tumor growth and proliferation. Its application in this area is of significant interest for the development of novel cancer treatments.
Used in Drug Design and Development:
In the field of drug design, (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is used as a structural template for the development of new drugs, particularly those targeting infectious diseases and cancer.
Used in Biochemical Research:
(E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is used as a research tool in biochemistry to study the interactions between various biomolecules and to understand the underlying mechanisms of diseases at the molecular level.
Overall, (E)-2-(2-hydroxybenzylidene)-N-phenylhydrazine-1-carbothioamide is a versatile and promising compound with a wide range of applications in the pharmaceutical, medical, and biochemical sectors, primarily due to its unique chemical structure and potential biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 1185908-30-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,9,0 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1185908-30:
(9*1)+(8*1)+(7*8)+(6*5)+(5*9)+(4*0)+(3*8)+(2*3)+(1*0)=178
178 % 10 = 8
So 1185908-30-8 is a valid CAS Registry Number.
1185908-30-8Relevant articles and documents
Synthesis, spectral and structural studies of zinc(II) complexes of salicylaldehyde N(4)-phenylthiosemicarbazone
Seena,Kurup, M.R. Prathapachandra
, p. 726 - 732 (2008)
Five Zn(II) complexes of salicylaldehyde N(4)-phenylthiosemicarbazone (H2L) have been synthesized and physicochemically characterized. Out of the five Zn(II) complexes, one is binuclear {[(ZnL)2]·3C2H5OH (1)} an
Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents
Bo-Wang,He, Zhang-Xu,Li, Yi-Han,Liu, Hong-Min,Ma, Li-Ying,Ma, Qin,Tao, Yuan-Yuan,Wang, Hao-Jie,Wu, Hui-Pan,Zhang, Xin-Hui,Zhao, Bing
, (2020/05/19)
In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound 5d displayed significant advantages in inhibition effect with an IC50 value of 0.031 μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved respectively). Besides, compound 5d showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound 5d could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, 5d could evidently suppress the cell migration and invasion by blocking the EMT (epithelial–mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.
Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity
Dilovic, Ivica,Rubcic, Mirta,Vrdoljak, Visnja,Pavelic, Sandra Kraljevic,Kralj, Marijeta,Piantanida, Ivo,Cindric, Marina
, p. 5189 - 5198 (2008/12/20)
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4-phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the po
