1186334-88-2

Basic information

• Product Name: tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• Synonyms: tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
• CAS NO: 1186334-88-2
• Molecular Weight: 350.845
• Mol File: 1186334-88-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(1186334-88-2)
• EPA Substance Registry System: tert-butyl(1S,4S)-5-(4-acetyl-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate(1186334-88-2)

Safety Data

• Hazardous Substances Data: 1186334-88-2(Hazardous Substances Data)

Upstream product

• 700-35-6 2'-chloro-4'-fluoroacetophenone 
• 113451-59-5 (1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Downstream Products

• 1186334-75-7 (1S,4S)-tert-butyl 5-(4-((E)-3-(dimethylamino)acryloyl)-3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 

Relevant articles and documents

Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity

Novel indazolylpyrazolo[1,5-a]pyrimidine analogues have been prepared and found to be extremely potent type I B-Raf inhibitors. The lead compound shows good selectivity against a panel of 60 kinases, possesses a desirable pharmacokinetic profile, and demonstrates excellent in vivo antitumor efficacy in B-Raf mutant xenograft models.