1186467-83-3

Basic information

• Product Name: (E)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoate
• Synonyms: (E)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoate
• CAS NO: 1186467-83-3
• Molecular Weight: 381.021
• Mol File: 1186467-83-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoate(1186467-83-3)
• EPA Substance Registry System: (E)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoate(1186467-83-3)

Safety Data

• Hazardous Substances Data: 1186467-83-3(Hazardous Substances Data)

Upstream product

• 346633-39-4 4-(3,5-dibromo-4-methoxybenzylidene)-2-methyloxazol-5(4H)-one 
• 74-88-4 methyl iodide 
• 6230-11-1 O-Methyltyrosine 

Downstream Products

• 1186467-84-4 (E)-3-(3,5-dibromo-4-methoxyphenyl)-2-(hydroxyimino)propanoic acid 
• 1357361-49-9 (E)-3-(3,5-dibromo-4-methoxyphenyl)-2-hydroxyimino-N-(12-(2-methylprop-2-oxy)carbamoyl-4,9-diazadodecyl)propanamide 
• 1338586-56-3 (E)-3-(3,5-dibromo-4-methoxyphenyl)-2-hydroxyimino-N-(3-(methylamino)propyl)propanamide 

Relevant articles and documents

Synthesis and anticancer evaluation of spermatinamine analogues

Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues

Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges

Herein we report the total syntheses of pseudoceramine A-D (2-5) and spermatinamine (1) isolated from the marine sponge Pseudoceratina sp. Direct acyl substitution of α-hydroxyiminoesters with amine nucleophiles was developed as a key transformation. The synthetic compounds confirm the reported structures and importantly gives access to non-symmetrical spermine based natural products carrying two different bromotyrosine building blocks. Our new synthesis of spermatinamine is two steps shorter and more efficient than the previously reported sequence. The Royal Society of Chemistry 2012.