1186523-50-1

Basic information

• Product Name: (S)-2-((R)-2-nitro-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexan-1-one
• Synonyms: (S)-2-((R)-2-nitro-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexan-1-one
• CAS NO: 1186523-50-1
• Molecular Weight: 315.292
• Mol File: 1186523-50-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-2-nitro-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-2-nitro-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexan-1-one(1186523-50-1)
• EPA Substance Registry System: (S)-2-((R)-2-nitro-1-(3-(trifluoromethyl)phenyl)ethyl)cyclohexan-1-one(1186523-50-1)

Safety Data

• Hazardous Substances Data: 1186523-50-1(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 115665-96-8 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene 
• 115665-96-8 m-Trifluormethyl-β-nitrostyrol 

Relevant articles and documents

Tropos biphenol derived chiral thiophosphoramide catalysed highly diastereo- and enantioselective michael addition of cyclic ketones to nitro olefins

Chirality transfer from (S)-2-(aminomethyl)pyrrolidine to the tropos biphenyl skeleton has been observed in the preparation of a chirally flexible biphenol-derived novel chiral thiophosphoramide to afford exclusively the thermodynamically favoured diaster

Chiral thiophosphoramidate-catalyzed asymmetric michael addition of ketones to nitro olefins

A novel type of pyrrolidine-based chiral (thio)phosphoramidates was synthesized. Among them, compound (S,aR)-3d was proven to be an effective bifunctional organocatalyst for the asymmetric Michael addition of ketones to nitro olefins. The corresponding adducts were obtained in good to excellent chemical yields with high levels of diastereo- and enantioselectivities (up to >99:1 dr and 99%ee).