118663-21-1

Basic information

• Product Name: 1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile
• Synonyms: 1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile
• CAS NO: 118663-21-1
• Molecular Formula: C16H18N4OS
• Molecular Weight: 314.40532
• Mol File: 118663-21-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile(118663-21-1)
• EPA Substance Registry System: 1-amino-5-(4-morpholinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile(118663-21-1)

Safety Data

• Hazardous Substances Data: 118663-21-1(Hazardous Substances Data)

Upstream product

• 952149-38-1 3-cyanomethylsulphanyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile 
• 50706-78-0 2,3,5,6,7,8-hexahydro-1-morpholin-4-yl-3-thioxo-isoquinoline-4-carbonitrile 
• 5275-11-6 3-amino-1-thioxo-2(1H)-5,6,7,8-tetrahydro-benzothiopyran-4-carbonitrile 
• 108-94-1 cyclohexanone 
• 50706-78-0 3-mercapto-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 
• 107-14-2 chloroacetonitrile 

Relevant articles and documents

INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF

Methods utilizing compounds and compositions are provided that comprise selective β-glucuronidase inhibitors. The methods can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs. The methods comprise administering the compounds in combination with agents or administering the compounds in a monotherapy for the treatment of cancer and gastrointestinal conditions.

Synthesis of morphlinotetrahydrothieno[2,3-c]isoquinolines

1-Morpholin-4-yl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (2) was synthesized from 3-amino-1-thioxo-5,6,7,8-tetrahydro-1H-isothiochromene-4- carbonitrile (1) and used as starting material to synthesize many thienotetrahydroisoquinolines (4), which in turn were used in the synthesis of many pyrimidothienotetrahydroisoquinolines.