118671-07-1

Basic information

• Product Name: 2-<(phenylmethyl)amino>benzeneacetonitrile
• Synonyms: 2-<(phenylmethyl)amino>benzeneacetonitrile
• CAS NO: 118671-07-1
• Molecular Weight: 222.29
• Mol File: 118671-07-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-<(phenylmethyl)amino>benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(phenylmethyl)amino>benzeneacetonitrile(118671-07-1)
• EPA Substance Registry System: 2-<(phenylmethyl)amino>benzeneacetonitrile(118671-07-1)

Safety Data

• Hazardous Substances Data: 118671-07-1(Hazardous Substances Data)

Upstream product

• 2973-50-4 2-aminophenylacetonitrile 
• 100-39-0 benzyl bromide 
• 100-52-7 benzaldehyde 

Downstream Products

• 10464-31-0 5H-N-benzyl-10,11-dihydrobenzazepin-10-one 
• 4698-11-7 10-methoxy-5H-dibenzo[b,f]azepine 
• 256-96-2 dibenzoazepine 
• 118671-36-6 1-Benzyl-2-oxo-1,2,3,4-tetrahydro-quinoline-4-carbonitrile 
• 118671-11-7 N-Benzyl-2-chloro-N-(2-cyanomethyl-phenyl)-acetamide 

Relevant articles and documents

3,9-DIAZASPIRO[5.5]UNDECANE COMPOUNDS

The present invention covers 3,9-diazaspiro[5.5]undecane compounds of general formula (I) and general formula (I-a), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Synihesis of 3-substituied indoles via a modified madeling reaction

Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt-Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.