1187-99-1

Basic information

• Product Name: 2-hydroxy-4-oxo-pentanedioic acid
• Synonyms: 2-hydroxy-4-oxo-pentanedioic acid;4-Hydroxy-2-oxoglutaric acid;2-keto-4-hydroxyglutarate;DL-4-Hydroxy-2-ketoglutarate;DL-4-Hydroxy-2-ketoglutarate DilithiuM Salt;4-Hydroxy-2-oxoglutaric acid lithium salt;DL-4-Hydroxy-2-ketoglutaric acid lithium salt;DL-KHG Li
• CAS NO: 1187-99-1
• Molecular Formula: C5H6O6
• Molecular Weight: 162.1
• Product Categories: Aliphatics;Enzyme substrates;Aliphatics, Enzyme substrates
• Mol File: 1187-99-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 425.6°Cat760mmHg
• Flash Point: 225.3°C
• Appearance: /
• Density: 1.7g/cm³
• Vapor Pressure: 5.01E-09mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: ?20°C
• Solubility: Water
• BRN: 1780096
• CAS DataBase Reference: 2-hydroxy-4-oxo-pentanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4-oxo-pentanedioic acid(1187-99-1)
• EPA Substance Registry System: 2-hydroxy-4-oxo-pentanedioic acid(1187-99-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1187-99-1(Hazardous Substances Data)

Usage

Description

2-Hydroxy-4-oxo-pentanedioic acid, also known as Glycerol, is an oxo dicarboxylic acid derived from glutaric acid with hydroxy and oxo substituents at the 2and 4-positions, respectively. It is an off-white solid and serves as a 4-substituted analog of Glutamic acid, making it a good enzyme substrate for GOT (glutamic oxalacetic aminotransferase).

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as an enzyme substrate for [application reason] its role as a 4-substituted analog of Glutamic acid, which makes it a good substrate for glutamic oxalacetic aminotransferase (GOT) [application type].
Used in Chemical Synthesis:
2-Hydroxy-4-oxo-pentanedioic acid is used as a chemical intermediate for [application reason] its unique structure and reactivity, which allows for the synthesis of various compounds and materials [application type].
Used in Cosmetics and Personal Care Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as a humectant and moisturizing agent for [application reason] its ability to retain moisture and improve the skin's hydration [application type].
Used in Food Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as a sweetener and humectant for [application reason] its sweetening properties and ability to retain moisture in the food products, enhancing their texture and shelf life [application type].
Used in Industrial Applications:
2-Hydroxy-4-oxo-pentanedioic acid is used as a component in the manufacturing of various products such as explosives, inks, and resins for [application reason] its versatile chemical properties and reactivity [application type].

InChI:InChI=1/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)

Upstream product

• 328-42-7 Oxalacetic acid 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 2485-33-8 (2S,4R)-4-hydroxyglutamic acid 
• 3913-68-6 threo-4-Hydroxy-L-glutamic acid 
• 3157-41-3 4-hydroxyglutamate 
• 82864-77-5 2,4-dihydroxy-glutaric acid 
• 91113-89-2 4-hydroxy-5-oxo-tetrahydro-furan-2-carboxylic acid 

Relevant articles and documents

Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase-transaminase recycling cascades

Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination. l-syn or anti-4-hydroxyglutamic acid and d-anti-4,5-dihydroxynorvaline were thus prepared in 83-95% yield in one step from simple substrates.