118718-59-5

Basic information

• Product Name: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 118718-59-5
• Molecular Formula: C₁₁H₉N₃O
• Molecular Weight: 199.20866
• Mol File: 118718-59-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 138-141℃ (ethanol water )
• Boiling Point: 358.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• PKA: -3.81±0.10(Predicted)
• CAS DataBase Reference: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(118718-59-5)
• EPA Substance Registry System: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(118718-59-5)

Safety Data

• Hazardous Substances Data: 118718-59-5(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile, also known as 4-methoxyphenylpyrazole-4-carbonitrile, is a chemical compound with the molecular formula C11H8N4O. It is a pyrazole derivative that contains a carbonitrile group. 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has potential biological and pharmacological activities, including as an analgesic and anti-inflammatory agent. The presence of the methoxyphenyl group in the molecule can influence its chemical and biological properties. 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile is important for research and development in the pharmaceutical and agricultural industries.

Upstream product

• 99984-70-0 1-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 116884-64-1 (5-amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carbonitrile) 
• 35715-67-4 1-(4-methoxyphenyl)-1H-pyrazole 

Downstream Products

• 1301185-12-5 1-(4-methoxyphenyl)-1H-pyrazole-4-carboximidamide 
• 1431459-44-7 5-[1-(4-methoxyphenyl)-1H-pyrazole-4-yl]-1H-tetrazole 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

An efficient synthesis of new 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] cycloaddition reaction

A series of new 5-(1-aryl-1H-pyrazole-4-yl)-1H-tetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl-1H-pyrazole-4- carbonitriles 3a-l, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64-85%. The structures of these newly synthesized compounds were determined from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.

New application of heterocyclic diazonium salts. Synthesis of pyrazolo[3,4-d][1,2,3]triazin-4-ones and imidazo[4,5-d][1,2,3]triazin-4-ones

The pyrazolo[3,4-d][1,2,3]triazin-4-ones 3 and imidazo[4,5-d][1,2,3] triazin-4-ones 4 are analogs structurally related to purines that have showed a wide and significant variety of biological activity. These compounds were synthesized by one-pot diazotization of 5-amino-1H-pyrazole-4-carbonitriles 1 and 5-amino-1H-imidazole-4-carbonitriles 2, respectively.