1187181-86-7

Basic information

• Product Name: 2'-methoxybiphenyl-4-carboxylic acid {4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide
• Synonyms: 2'-methoxybiphenyl-4-carboxylic acid {4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide
• CAS NO: 1187181-86-7
• Molecular Weight: 503.641
• Mol File: 1187181-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-methoxybiphenyl-4-carboxylic acid {4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-methoxybiphenyl-4-carboxylic acid {4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide(1187181-86-7)
• EPA Substance Registry System: 2'-methoxybiphenyl-4-carboxylic acid {4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide(1187181-86-7)

Safety Data

• Hazardous Substances Data: 1187181-86-7(Hazardous Substances Data)

Upstream product

• 5728-32-5 4-(2-methoxyphenyl)benzoic acid 

Relevant articles and documents

SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment associated with a variety of disorders including Alzheimer's disease and schizophrenia. Alpha 7 nAChRs are expressed in brain regions associated with cognitive function, regulate cholinergic neurotransmission and have been shown to be down regulated in both schizophrenia and Alzheimer's disease. Herein we report a novel, potent small molecule agonist of the alpha 7 nAChR, SEN12333/WAY-317538. This compound is a selective agonist of the α7 nAChR with excellent in vitro and in vivo profiles, excellent brain penetration and oral bioavailability, and demonstrates in vivo efficacy in multiple behavioural cognition models. The SAR and biological evaluation of this series of compounds are discussed.