1187856-42-3

Basic information

• Product Name: tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate
• Synonyms: tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate
• CAS NO: 1187856-42-3
• Molecular Weight: 258.358
• Mol File: 1187856-42-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate(1187856-42-3)
• EPA Substance Registry System: tert-butyl 2-(((1r,4r)-4-(hydroxymethyl)cyclohexyl)methoxy)acetate(1187856-42-3)

Safety Data

• Hazardous Substances Data: 1187856-42-3(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 

Downstream Products

• 1187857-84-6 tert-butyl 2-(((1r,4r)-4-((4-chlorophenylcarbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187856-74-1 tert-butyl 2-(((1r,4r)-4-((3-fluorophenylcarbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187857-83-5 2-(((1r,4r)-4-(((4-chlorophenyl)(4-hydroxyphenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187857-69-7 2-(((1r,4r)-4-((benzhydryl(propyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187857-65-3 2-(((1r,4r)-4-((benzhydryl(methyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187856-39-8 2-(((1r,4r)-4-(((2,3-difluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187856-79-6 2-(((1r,4r)-4-(((4-chloro-3-fluorophenyl)(3-fluorophenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187856-75-2 2-(((1r,4r)-4-(((4-fluorophenyl)(3-fluorophenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1349986-32-8 2-(((1r,4r)-4-(((4-chlorophenyl)(3-fluorophenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 

Relevant articles and documents

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in