1187857-80-2

Basic information

• Product Name: 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid
• Synonyms: 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid
• CAS NO: 1187857-80-2
• Molecular Weight: 539.049
• Mol File: 1187857-80-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid(1187857-80-2)
• EPA Substance Registry System: 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid(1187857-80-2)

Safety Data

• Hazardous Substances Data: 1187857-80-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 106-47-8 4-chloro-aniline 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 
• 1187856-46-7 tert-butyl 2-(((1r,4r)-4-(((4-chlorophenyl)-(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187856-49-0 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid 
• 1187856-44-5 (4-chlorophenyl)(phenyl)carbamic chloride 
• 108-86-1 bromobenzene 
• 106-39-8 bromochlorobenzene 
• 1187856-45-6 ((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl (4-chlorophenyl)(phenyl)carbamate 
• 1187856-43-4 sodium 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate 
• 1187857-74-4 N-(4-chlorophenyl)-N-phenyl-1H-imidazole-1-carboxamide 
• 1205-71-6 N-(4-chlorophenyl)aniline 
• 107-35-7 Tau 
• 1187857-81-3 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid chloride 

Downstream Products

• 1278584-02-3 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid tris(hydroxymethyl)aminomethane salt 
• 1278583-96-2 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid potassium salt 
• 1278584-01-2 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid sodium salt 

Relevant articles and documents

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in

MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to metho