118806-75-0Relevant articles and documents
Simple synthesis and biological evaluation of flocoumafen and its structural isomers
Jung, Jae-Chul,Jang, Soyong,Oh, Seikwan,Park, Oee-Sook
, p. 833 - 838 (2011/10/04)
Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 μM in vitro, while no significant effect for neurotoxicity in cultured cortical neurons. Indian Academy of Sciences.