1188265-45-3 Usage
Clinical Use
Treatment of schizophrenia
Adjunctive treatment in palliative care
Nausea and vomiting
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with
tramadol; increased hypotension and sedation
with opioid analgesics; increased risk of ventricular
arrhythmias with methadone.
Anti-arrhythmics: increased risk of ventricular
arrhythmias due to prolongation of QT interval;
increased risk of ventricular arrhythmias with
amiodarone, disopyramide and dronedarone - avoid.
Antibacterials: increased risk of ventricular
arrhythmias with delamanid and moxifloxacin -
avoid.
Antidepressants: possibly increased concentration
of tricyclics, increased antimuscarinic effects and
ventricular arrhythmias; avoid with MAOIs (2
fatalities have been reported); risk of ventricular
arrhythmias with citalopram and escitalopram -
avoid; possible increased risk of convulsions with
vortioxetine.
Anticonvulsant: lowers anticonvulsant threshold.
Antihypertensives: enhanced hypotensive effect;
increased risk of ventricular arrhythmias with sotalol.
Antimalarials: avoid with artemether/lumefantrine
and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular
arrhythmias with droperidol, pimozide and
risperidone - avoid.
Antivirals: concentration possibly increased by
ritonavir; increased risk of ventricular arrhythmias
with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedation.
Atomoxetine: increased risk of ventricular
arrhythmias.
Cytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal effects and
neurotoxicity.
Pentamidine: increased risk of ventricular
arrhythmias - avoid.
Check Digit Verification of cas no
The CAS Registry Mumber 1188265-45-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,8,2,6 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1188265-45:
(9*1)+(8*1)+(7*8)+(6*8)+(5*2)+(4*6)+(3*5)+(2*4)+(1*5)=183
183 % 10 = 3
So 1188265-45-3 is a valid CAS Registry Number.
1188265-45-3Relevant articles and documents
Photooxidation mechanism of levomepromazine in different solvents
Pinero-Santiago, Luis E.,Garcia, Carmelo,Lhiaubet-Vallet, Virginie,Trzcionka, Jerome,Oyola, Rolando,Torres, Karen,Leguillu, Jaysika,Miranda, Miguel A.
, p. 1479 - 1489 (2013)
Unwanted photoinduced responses are well-known adverse effects of most promazine drugs, including levomepromazine (LPZ, Levoprome or Nozinan). This drug is indicated in psychiatry primarily for the treatment of schizophrenia and other schizoaffective disorders. Levomepromazine's particular sedative properties make it especially fit for use in psychiatric intensive care. Nevertheless, it is photolabile under UV-A and UV-B light in aerobic conditions resulting in the formation of its sulfoxide. The LPZ photochemistry in acetonitrile (MeCN) is completely different from that in methanol (MeOH) and phosphate buffer solutions (PBS, pH = 7.4). The major photoproduct in PBS and MeOH under aerobic conditions is levomepromazine sulfoxide (LPZSO), although the amount is considerably higher in the aqueous environment. The corresponding main photoproduct in MeCN could not be characterized. The destruction quantum yields of LPZ in PBS, MeOH and MeCN are 0.13, 0.02 and -3, respectively. It is further demonstrated that LPZSO does not form by the reaction of singlet oxygen with ground-state LPZ. This oxidation product is actually produced by the reaction of the cation radical of LPZ (LPZ·+) with molecular oxygen. This cation radical in turn, is produced by an electron transfer process between the 3LPZ* and ground-state molecular oxygen.
Convenient oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid
Owens,Juenge,Poklis
, p. 334 - 336 (2007/10/02)
A simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.
