118837-66-4

Basic information

• Product Name: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE
• Synonyms: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE;N-ISOPROPYL 3-AMINOBENZENESULFONAMIDE;3-Amino-N-isopropylbenzenesulphonamide;3-Amino-N-isopropylbenzenesulphonamide 98%;3-Amino-N-(prop-2-yl)benzenesulphonamide, 3-(N-Isopropylsulphamoyl)aniline;3-Amino-N-isopropylbenzenesulphonamide98%
• CAS NO: 118837-66-4
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28466
• Product Categories: Amines;blocks;Sulfonamides
• Mol File: 118837-66-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 384 °C at 760 mmHg
• Flash Point: 186 °C
• Appearance: /
• Density: 1.219 g/cm³
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE(118837-66-4)
• EPA Substance Registry System: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE(118837-66-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 118837-66-4(Hazardous Substances Data)

Usage

General Description

3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE is a chemical compound also known by the trade name Tolvaptan. It is a sulfonamide derivative with a molecular formula C10H15N3O2S and a molecular weight of 249.31 g/mol. 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE is used as a selective vasopressin V2-receptor antagonist and is primarily used in the treatment of hyponatremia (low sodium levels in the blood) and fluid retention in patients with heart failure, liver cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH). 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE works by blocking the effects of vasopressin, leading to increased excretion of water by the kidneys. It is typically administered in oral form and is available by prescription only. Side effects may include thirst, dry mouth, headache, and dizziness.

InChI:InChI=1/C9H14N2O2S/c1-7(2)11-14(12,13)9-5-3-4-8(10)6-9/h3-7,11H,10H2,1-2H3

Upstream product

• 28860-10-8 N-methylethyl-3-nitrobenzenesulfonamide 

Downstream Products

• 1241892-01-2 C₁₉H₁₇ClN₂O₄S 

Relevant articles and documents

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.