118854-49-2 Usage
Description
4-Isopropoxy-2-methyl-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid pyridin-2-ylamide, also known as 2-Methyl-4-(1-methylethoxy)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide, is a chemical compound that serves as an impurity in Piroxicam, a non-steroidal anti-inflammatory drug with a long half-life. 4-Isopropoxy-2-methyl-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid pyridin-2-ylamide is characterized by its unique molecular structure, which includes a benzothiazine core, an isopropoxy group, a methyl group, and a pyridinyl amide moiety.
Uses
Used in Pharmaceutical Industry:
4-Isopropoxy-2-methyl-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid pyridin-2-ylamide is used as an impurity in the production of Piroxicam (P510000), a non-steroidal anti-inflammatory drug. Its presence in Piroxicam is significant as it can affect the drug's efficacy, safety, and quality. Therefore, monitoring and controlling the levels of this impurity are crucial in ensuring the overall performance and reliability of Piroxicam as a pharmaceutical product.
As an impurity, 4-Isopropoxy-2-methyl-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid pyridin-2-ylamide may also be a subject of research and development efforts aimed at understanding its potential effects on the drug's pharmacological properties and identifying ways to minimize or eliminate its presence in the final product. This can involve the development of advanced synthesis methods, purification techniques, or alternative formulations to improve the purity and quality of Piroxicam and other related pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 118854-49-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,8,5 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 118854-49:
(8*1)+(7*1)+(6*8)+(5*8)+(4*5)+(3*4)+(2*4)+(1*9)=152
152 % 10 = 2
So 118854-49-2 is a valid CAS Registry Number.
118854-49-2Relevant articles and documents
Reactions of Piroxicam with Alkyl Iodides
Hammen, Philip D.,Berke, Helen,Bordner, Jon,Braisted, Andrew C.,Lombardino, Joseph G.,Whipple, Earl B.
, p. 11 - 16 (2007/10/02)
Alkylation of piroxicam with a homologous series of alkyl iodides gave reversibly formed O-alkyl products 1 as well as unexpected, irreversibly formed zwitterionic compounds 2, alkylated on the pyridine nitrogen, and O,N-bis-alkyl products 3.Proof of structure was accomplished by nmr and X-ray crystal analysis.Product distribution ratios were determined by hplc and are explained by the Hard-Soft Acid-Base principle.
