118892-73-2Relevant articles and documents
Novel synthesis method of 3-fluoropyridine-2-methanol
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, (2020/04/22)
The invention relates to the field of compound preparation, in particular to a novel synthesis method of 3-fluoropyridine-2-methanol. The 3-fluoropyridine-2-methanol has a structure as shown in a formula V. According to the synthesis method, cheap quinolinic acid is used as an initial raw material, the target product namely 3-fluoropyridine-2-methanol is obtained through the steps of anhydride, esterification, ammoniation, amino fluorination, ester group reduction, and the like, and the structure of the target product is characterized by 1HNMR and 13CNMR. The synthetic method is a brand new synthetic method of 3-fluoropyridine-2-methanol, and has the advantages of low cost, simple technology, high yield, good quality, and high industrialization value.
Three substituted naphthyridine compounds and its preparation and use
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Paragraph 0061-0063, (2017/04/14)
The invention relates to 1,3,5-tri-substituted-1H-imidazo[4,5-h]1,6-diazanaphthalene-2(3H)-one compounds shown as the general formula I, isomers thereof and pharmaceutically acceptable salts thereof, a preparation method and applications thereof, and comp
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties
Zeng, Li-Fan,Wang, Yong,Kazemi, Roza,Xu, Shili,Xu, Zhong-Liang,Sanchez, Tino W.,Yang, Liu-Meng,Debnath, Bikash,Odde, Srinivas,Xie, Hua,Zheng, Yong-Tang,Ding, Jian,Neamati, Nouri,Long, Ya-Qiu
, p. 9492 - 9509 (2013/01/16)
Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1,6]naphthyridines (i.e., L-870,810) were one of the promising class of antiretroviral drugs developed by Merck Laboratories. In spite of its remarkable potency and efficacy, unfortun