1189176-86-0

Basic information

• Product Name: 2-(4,5-dimethylpyrimidin-2-ylthio)-1-(2,3,4-trimethoxyphenyl)ethanone
• CAS NO: 1189176-86-0
• Molecular Weight: 348.423
• Mol File: 1189176-86-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4,5-dimethylpyrimidin-2-ylthio)-1-(2,3,4-trimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,5-dimethylpyrimidin-2-ylthio)-1-(2,3,4-trimethoxyphenyl)ethanone(1189176-86-0)
• EPA Substance Registry System: 2-(4,5-dimethylpyrimidin-2-ylthio)-1-(2,3,4-trimethoxyphenyl)ethanone(1189176-86-0)

Safety Data

• Hazardous Substances Data: 1189176-86-0(Hazardous Substances Data)

Upstream product

• 54109-14-7 α-bromo-2',3',4'-trimethoxyacetophenone 
• 64942-98-9 4,5-Dimethylpyrimidin-2-thiol 

Relevant articles and documents

Novel 2,4,5-trisubstituted oxazole derivatives: Synthesis and antiproliferative activity

Microwave irradiation promotes the rapid O,N-acylation-cyclodehydration cascade reaction of oximes and acid chloride. Twenty novel 2,4,5-trisubstituted oxazole derivatives containing heterocycle moiety were synthesized and evaluated for their antiproliferative activity. The twenty compounds are all first reported and their structures were established by elemental analysis, 1H NMR and 13C NMR spectra. The bioassay tests showed that compounds 2-(2-(2-fluorophenyl)-4-(2,3,4-trimethoxyphenyl)oxazol-5-ylthio)benzo[d]thiazole (6af), 2-(2-(pyridin-3-yl)-4-(2,3,4-trimethoxyphenyl)oxazol-5-ylthio)pyrimidine (6bg) and 2-(2-(2-fluorophenyl)-4-(2,3,4-trimethoxyphenyl)oxazol-5-ylthio)-5-methyl-1,3,4-thiadiazole (6cf) displayed good antiproliferative activity in vitro, which were comparable to the positive control (5-fluorouracil).