118918-05-1

Basic information

• Product Name: trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one
• Synonyms: trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one
• CAS NO: 118918-05-1
• Molecular Weight: 438.434
• Mol File: 118918-05-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one(118918-05-1)
• EPA Substance Registry System: trans-(4R,6S)-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one(118918-05-1)

Safety Data

• Hazardous Substances Data: 118918-05-1(Hazardous Substances Data)

Upstream product

• 118874-96-7 ethyl (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoate 
• 123185-91-1 cis-(4R,6S)-2,2-dimethyl-6-formyl-1,3-dioxane-4-acetic acid 
• 123185-87-5 tert-butyl (3R,5S)-6-oxo-3,5-dihydroxy-3,5-O-isopropylidenehexanoate 
• 118845-89-9 cis-(4R,6S)-6-<4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl>-2,2-dimethyl-1,3-dioxane-4-acetic acid 
• 118845-72-0 dimethyl <3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propen-1-yl>phosphonate 
• 109519-27-9 methyl (3S^*,5R^*)-3,5-isopropylidenedioxy-7-phenyl-6-heptenoate 
• 123185-86-4 t-butyl (3S^*,5R^*,6E)-7-phenyl-3,5-isopropylidenedioxy-6-heptenoate 
• 123185-85-3 tert-butyl cis-3,5-dihydroxy-7-phenylhept-6-enoate 
• 129785-03-1 (E)-(3R,5S)-9,9-Bis-(4-fluoro-phenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-nona-6,8-dienoic acid 
• 130273-24-4 ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(1-methyl-1H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate 
• 118875-67-5 1,1-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)propanol 
• 118846-05-2 3,3-bis(4-fluorophenyl)-1-bromo-2-(1-methyl-1H-tetrazol-5-yl)-2-propene 
• 118875-68-6 5-[2,2-bis(4-fluorophenyl)-1-methylethenyl]-1-methyl-1H-tetrazole 
• 118875-43-7 (+/-)-erythro-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-6,8-nonadienoic acid 

Downstream Products

• 130320-56-8 BMY-21950 

Relevant articles and documents

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Compounds of the formula STR1 wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen C1-4 alkyl or C1-4 alkoxy; tet is STR2 n is an integer of from 0 to 2, inclusive; A is STR3 R7 is hydrogen, C1-4 alkyl, C1-4 alkoxy(lower) alkyl or (2-methoxyethoxy)methyl; X is --OH or =O; and R8 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.

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