118959-44-7

Basic information

• Product Name: 1-methyl-1H-Indole-3-carboxamide
• Synonyms: 1-methyl-1H-Indole-3-carboxamide
• CAS NO: 118959-44-7
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 118959-44-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-methyl-1H-Indole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1H-Indole-3-carboxamide(118959-44-7)
• EPA Substance Registry System: 1-methyl-1H-Indole-3-carboxamide(118959-44-7)

Safety Data

• Hazardous Substances Data: 118959-44-7(Hazardous Substances Data)

Usage

Description

1-methyl-1H-Indole-3-carboxamide, also known as 3-Methylindole-3-carboxylic acid amide, is a chemical compound with the molecular formula C9H8N2O. It is a derivative of indole, a heterocyclic aromatic compound. This versatile compound is known for its various biological activities, including anti-inflammatory and anticancer properties, and is widely used in the synthesis of organic compounds, pharmaceuticals, dyes, pigments, and biochemicals.

Uses

Used in Pharmaceutical Industry:
1-methyl-1H-Indole-3-carboxamide is used as an intermediate in the synthesis of pharmaceuticals for its potential anti-inflammatory and anticancer properties, contributing to the development of new drugs that can address these health concerns.
Used in Chemical Industry:
As a starting material, 1-methyl-1H-Indole-3-carboxamide is used in the synthesis of a wide range of organic compounds, highlighting its importance in the creation of various chemical products.
Used in Dye and Pigment Production:
1-methyl-1H-Indole-3-carboxamide is utilized in the production of various dyes and pigments, owing to its chemical properties that lend themselves to color creation and application in different industries.
Used in Biochemical Synthesis:
1-methyl-1H-Indole-3-carboxamide serves as a starting material for the synthesis of a broad spectrum of biochemicals, further expanding its applications in the field of chemistry and beyond.

Upstream product

• 603-76-9 1-methylindole 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 125818-09-9 methyl 1-methyl-1H-indole-3-carboxamidate hydrochloride 
• 24662-37-1 1-methyl-1H-indole-3-carbonitrile 
• 32387-21-6 1-methyl-3-indolecarboxylic acid 
• 390799-61-8 1-methylindole-3-carboxamidine E-oxime 
• 571151-09-2 (1-methyl-1H-indole-3-carbonyl)-phosphoramidic acid 
• 5457-28-3 3-cyano-1H-indole 
• 228566-47-0 C₁₀H₉Cl₂N₂O₂P 
• 942-24-5 3-methoxycarbonylindole 
• 108438-43-3 methyl 1-methyl-1H-indole-3-carboxylate 
• 19012-03-4 N-methyl-3-formylindole 
• 24666-30-6 1-methyl-1H-indole-3-carbaldehyde oxime 
• 120-72-9 indole 

Relevant articles and documents

Synthesis and antitumor activity of new thiazole nortopsentin analogs

New thiazole nortopsentin analogs in which one of the two indole units was replaced by a naphthyl and/or 7-azaindolyl portion, were conveniently synthesized. Among these, three derivatives showed good antiproliferative activity, in particular against MCF7 cell line, with GI50 values in the micromolar range. Their cytotoxic effect on MCF7 cells was further investigated in order to elucidate their mode of action. Results showed that the three compounds act as pro-apoptotic agents inducing a clear shift of viable cells towards early apoptosis, while not exerting necrotic effects. They also caused cell cycle perturbation with significant decrease in the percentage of cells in the G0/G1 and S phases, accompanied by a concomitant percentage increase of cells in the G2/M phase, and appearance of a subG1-cell population.

Synthesis and antiproliferative activity of substituted 3[2-(1h-indol-3-yl)- 1,3-thiazol-4-yl]-1h-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues

A large number of indolyl-4-azaindolyl thiazoles, nortopsentin analogues, were conveniently synthesized. The antiproliferative activity of the new derivatives was examined against four human tumor cell lines with different histologic origin. Seven derivatives consistently reduced the growth of the experimental models independently of TP53 gene status and exhibited the highest activity against the malignant peritoneal mesothelioma (STO) cell line. The most active compound of this series acts as a CDK1 inhibitor, and was found to cause cell cycle arrest at G2/M phase, to induce apoptosis by preventing the phosphorylation of survivin in Thr34 and to increase the cytotoxic activity of paclitaxel in STO cells.

Au/Ag-cocatalyzed aldoximes to amides rearrangement under solvent- and acid-free conditions

(Chemical Equation Presented) The gold/silver-cocatalyzed conversion of aldoximes into primary amides is reported. The reaction, which proceeds under neat and acid-free conditions, allows for the conversion of a range of aldoximes, and is a rare example of cooperative catalysis involving well-defined gold species.