1190208-79-7

Basic information

• Product Name: C₂₂H₂₈ClNO₄S
• Synonyms: C₂₂H₂₈ClNO₄S
• CAS NO: 1190208-79-7
• Molecular Weight: 437.988
• Mol File: 1190208-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₈ClNO₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₈ClNO₄S(1190208-79-7)
• EPA Substance Registry System: C₂₂H₂₈ClNO₄S(1190208-79-7)

Safety Data

• Hazardous Substances Data: 1190208-79-7(Hazardous Substances Data)

Upstream product

• 1190208-78-6 N-methyl-N-[2-(2-oxoethyl)phenyl]carbamic acid tert-butyl ester 
• 31350-91-1 (R)-chloromethyl p-tolyl sulfoxide 

Downstream Products

• 1190208-80-0 C₂₃H₃₀ClNO₆S₂ 

Relevant articles and documents

Asymmetric synthesis of cyclic α-amino acid derivatives by the intramolecular reaction of magnesium carbenoid with an N-magnesio arylamine

The synthesis of pipecolic acid and homopipecolic acid derivatives was developed from ω-(2-aminophenyl)-1-chloroalkyl p-tolyl sulfoxides by treatment with i-PrMgCl. An intramolecular nucleophilic substitution reaction of a magnesium carbenoid with an N-magnesio arylamine is the key step of this reaction. Proline and pipecolic acid derivatives were also synthesized from ω-(arylamino)-1-chloroalkyl p-tolyl sulfoxides by the same chemistry. Starting from enantiomerically pure (1S,RS)-1-chloro-3-[2-(N-methylamino)phenyl]propyl p-tolyl sulfoxide, enantiomerically pure (R)-pipecolic acid derivative was obtained. The intramolecular nucleophilic substitution reaction of the magnesium carbenoid with N-magnesio arylamine was proven to take place with inversion of the carbenoid carbon. The stereochemistry of these reactions is also discussed.