1190747-05-7Relevant articles and documents
2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer
Chen, Zecheng,Venkatesan, Aranapakam M.,Dehnhardt, Christoph M.,Santos, Osvaldo Dos,Santos, Efren Delos,Ayral-Kaloustian, Semiramis,Chen, Lei,Geng, Yi,Arndt, Kim T.,Lucas, Judy,Chaudhary, Inder,Mansour, Tarek S.
scheme or table, p. 4980 - 4983 (2010/03/24)
The synthesis and SAR of a series of 2,4-diamino-quinazoline derivatives as β-catenin/Tcf-4 inhibitors are described. This series was developed by modifying the initial lead 1, which was identified by screening of our compound library and found to inhibit
