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1190861-43-8

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1190861-43-8 Usage

Description

6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is a chemical compound characterized by its unique spirocyclic structure, which incorporates a bromine atom and a pyran ring. 6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is recognized for its potential as a building block in the synthesis of pharmaceuticals and bioactive compounds due to its distinctive structural features.

Uses

Used in Pharmaceutical Synthesis:
6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is utilized as a key intermediate in the development of various pharmaceuticals and bioactive compounds. Its unique structure allows for the creation of new drug candidates with potential therapeutic applications.
Used in Antifungal Applications:
In the field of antifungal agents, 6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is employed for its potential to combat fungal infections, providing a new avenue for the treatment of various fungal diseases.
Used in Antibacterial Applications:
6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one also serves as an antibacterial agent, contributing to the development of new antibiotics to address the growing concern of antibiotic resistance.
Used in Anticancer Applications:
6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is being studied for its potential as an anticancer agent, with ongoing research exploring its ability to target and inhibit the growth of cancer cells.
Used in Neurological Disorder Treatment:
6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is being investigated for its potential use in the treatment of neurological disorders, suggesting a possible role in managing or alleviating symptoms associated with such conditions.
Used as an Anti-Inflammatory Agent:
6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one is also being explored for its anti-inflammatory properties, indicating a potential application in reducing inflammation and associated symptoms in various conditions.
Further research is necessary to fully understand and harness the potential applications of 6-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one in drug development and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1190861-43-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,0,8,6 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1190861-43:
(9*1)+(8*1)+(7*9)+(6*0)+(5*8)+(4*6)+(3*1)+(2*4)+(1*3)=158
158 % 10 = 8
So 1190861-43-8 is a valid CAS Registry Number.

1190861-43-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromospiro[1H-indole-3,4'-oxane]-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1190861-43-8 SDS

1190861-43-8Relevant articles and documents

Preparation Method for Amide Compounds and Use Thereof in Medical Field

-

, (2022/02/06)

Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors

Gonzalez-Lopez De Turiso, Felix,Shin, Youngsook,Brown, Matthew,Cardozo, Mario,Chen, Yi,Fong, David,Hao, Xiaolin,He, Xiao,Henne, Kirk,Hu, Yi-Ling,Johnson, Michael G.,Kohn, Todd,Lohman, Julia,McBride, Helen J.,McGee, Lawrence R.,Medina, Julio C.,Metz, Daniela,Miner, Kent,Mohn, Deanna,Pattaropong, Vatee,Seganish, Jennifer,Simard, Jillian L.,Wannberg, Sharon,Whittington, Douglas A.,Yu, Gang,Cushing, Timothy D.

, p. 7667 - 7685 (2012/10/29)

Structure-based rational design led to the synthesis of a novel series of potent PI3K inhibitors. The optimized pyrrolopyridine analogue 63 was a potent and selective PI3Kβ/δ dual inhibitor that displayed suitable physicochemical properties and pharmacokinetic profile for animal studies. Analogue 63 was found to be efficacious in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis (CIA) disease model of rheumatoid arthritis. These studies highlight the potential therapeutic value of inhibiting both the PI3Kβ and δ isoforms in the treatment of a number of inflammatory diseases.

HETEROCYCLIC COMPOUNDS AND THEIR USES

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Page/Page column 35; 49, (2011/01/12)

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

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