1190862-16-8

Basic information

• Product Name: dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate
• Synonyms: dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate
• CAS NO: 1190862-16-8
• Molecular Weight: 485.291
• Mol File: 1190862-16-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate(1190862-16-8)
• EPA Substance Registry System: dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate(1190862-16-8)

Safety Data

• Hazardous Substances Data: 1190862-16-8(Hazardous Substances Data)

Upstream product

• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 15014-25-2 malonic acid dibenzyl ester 

Downstream Products

• 1190319-62-0 6-bromo-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one 

Relevant articles and documents

Indolin-2-one p38α inhibitors II: Lead optimisation

Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.

New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.