1190886-60-2

Basic information

• Product Name: C₂₃H₂₃F₂N₃O₂
• CAS NO: 1190886-60-2
• Molecular Weight: 411.451
• Mol File: 1190886-60-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₃F₂N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₃F₂N₃O₂(1190886-60-2)
• EPA Substance Registry System: C₂₃H₂₃F₂N₃O₂(1190886-60-2)

Safety Data

• Hazardous Substances Data: 1190886-60-2(Hazardous Substances Data)

Upstream product

• 1190862-23-7 6'-bromospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridine]-2',4(1'H)-dione 
• 1190319-62-0 6-bromo-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one 
• 515135-67-8 N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)benzamide 
• 1190862-25-9 6'-bromo-4,4-difluorospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridin]-2'(1'H)-one 

Relevant articles and documents

Indolin-2-one p38α inhibitors II: Lead optimisation

Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.