1190897-55-2

Basic information

• Product Name: C₁₉H₂₅N₃O₃
• Synonyms: C₁₉H₂₅N₃O₃
• CAS NO: 1190897-55-2
• Molecular Weight: 343.426
• Mol File: 1190897-55-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₅N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₅N₃O₃(1190897-55-2)
• EPA Substance Registry System: C₁₉H₂₅N₃O₃(1190897-55-2)

Safety Data

• Hazardous Substances Data: 1190897-55-2(Hazardous Substances Data)

Upstream product

• 141642-82-2 5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 555-96-4 Benzylhydrazine 
• 100-39-0 benzyl bromide 

Downstream Products

• 1190897-42-7 C₁₄H₁₇N₃O 
• 851376-82-4 1-benzyl-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-1H-1,2,6-triazaazulene-6-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence

A range of heterocycle fused azepines were synthesized in order to find a CNS penetrant, selective 5-HT2C agonist for the treatment of incontinence. The pyridazo-azepines such as compound 11 were shown to be potent 5-HT2C agonists and have potential for CNS penetration and good in vitro ADME properties but lacked selectivity against 5-HT2B. Fusing a further heterocycle gave the selective triazolopyrimido-azepines. An example of this series, compound 36, was shown to be potent, selective, metabolically stable in vitro and efficacious in an in vivo model of stress urinary incontinence.