1190924-53-8Relevant articles and documents
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Tanis, Virginia M.,Bacani, Genesis M.,Blevitt, Jonathan M.,Chrovian, Christa C.,Crawford, Shelby,De Leon, Aimee,Fourie, Anne M.,Gomez, Laurent,Grice, Cheryl A.,Herman, Krystal,Kearney, Aaron M.,Landry-Bayle, Adrienne M.,Lee-Dutra, Alice,Nelson, Jay,Riley, Jason P.,Santillán Jr., Alejandro,Wiener, John J.M.,Xue, Xiaohua,Young, Arlene L.
, p. 7504 - 7511 (2013/02/22)
Previously, benzthiazole containing LTA4H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering c Log