1191126-45-0

Basic information

• Product Name: 2-{[hydroxy(phenyl)phosphinoyl]methyl}-4-methylpent-4-enoic acid
• Synonyms: 2-{[hydroxy(phenyl)phosphinoyl]methyl}-4-methylpent-4-enoic acid
• CAS NO: 1191126-45-0
• Molecular Weight: 268.249
• Mol File: 1191126-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{[hydroxy(phenyl)phosphinoyl]methyl}-4-methylpent-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[hydroxy(phenyl)phosphinoyl]methyl}-4-methylpent-4-enoic acid(1191126-45-0)
• EPA Substance Registry System: 2-{[hydroxy(phenyl)phosphinoyl]methyl}-4-methylpent-4-enoic acid(1191126-45-0)

Safety Data

• Hazardous Substances Data: 1191126-45-0(Hazardous Substances Data)

Upstream product

• 1779-48-2 phenylphosphinic acid 
• 814-68-6 acryloyl chloride 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 818-67-7 acrylic acid methallyl ester 

Relevant articles and documents

A modular rearrangement approach toward medicinally relevant phosphinic structures

An unprecedented coupling of a P - C and a C - C bond-forming event In a practical operation was developed to access medicinally relevant phosphinic structures. The strategy relies on an Ireland-Claisen rearrangement triggered by the phospha-Michael addition of silyl phosphonltes to allyl acrylates. This protocol was extended to a more versatile three-component variant that utilizes phosphinic acids, acryloyl chlorides, and allylic alcohols as starting materials.