1192-72-9

Basic information

• Product Name: 4,5-DIMETHYL-1H-IMIDAZOLE-2-THIOL
• Synonyms: 2-MERCAPTO-4,5-DIMETHYLIMIDAZOLE;4,5-DIMETHYL-1H-IMIDAZOLE-2-THIOL;4,5-DIMETHYLIMIDAZOLE-2-THIOL
• CAS NO: 1192-72-9
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 128.2
• Mol File: 1192-72-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: >280°C
• Boiling Point: 179.8 °C at 760 mmHg
• Flash Point: 62.5 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.925mmHg at 25°C
• Refractive Index: 1.612
• PKA: 11.50±0.70(Predicted)
• CAS DataBase Reference: 4,5-DIMETHYL-1H-IMIDAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIMETHYL-1H-IMIDAZOLE-2-THIOL(1192-72-9)
• EPA Substance Registry System: 4,5-DIMETHYL-1H-IMIDAZOLE-2-THIOL(1192-72-9)

Safety Data

• Hazardous Substances Data: 1192-72-9(Hazardous Substances Data)

Usage

General Description

4,5-Dimethyl-1H-imidazole-2-thiol, also known as 4,5-Dimethylimidazole-2(1H)-thione or 4,5-dimethyl-1H-imidazole-2(3H)-thione, is a synthetic chemical compound with the molecular formula C5H8N2S. Chemically classified as an imidazole, it is a heterocyclic compound with a five-member ring consisting of two nitrogen atoms and two carbon atoms in its structure. It's characterized by its foul, rotten egg-like smell. However, beyond this limited information, there are currently no readily available details on its applications or potential effects. Essential safety measures should be taken while handling this chemical due to the limited knowledge on its toxicity.

InChI:InChI=1/C5H8N2S/c1-3-4(2)7-5(8)6-3/h1-2H3,(H2,6,7,8)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 108-24-7 acetic anhydride 
• 302-72-7 rac-Ala-OH 
• 333-20-0 potassium thioacyanate 
• 2198-64-3 N-Benzoylalanine 
• 135636-66-7 butane-2,3-dione mono-oxime 
• 513-86-0 3-hydroxy-2-butanon 
• 17356-08-0 thiourea 

Downstream Products

• 2302-39-8 4,5-dimethylimidazole 
• 1020662-86-5 C₁₄H₁₁ClN₂OS 
• 1125455-45-9 2-(4-methoxybenzylsulfanyl)-4,5-dimethyl-1H-imidazole 
• 75-64-9 tert-butylamine 

Relevant articles and documents

1,4,5-Trialkyl imidazole system anti-inflammatory properties of new substituted derivatives

In an investigation of the anti-inflammatory properties of five-membered ring nitrogen-containing heterocyclic compounds, two series of derivatives of imidazole were prepared by altering the sites of substitution and by joining aliphatic chains to the nitrogen atom in the 1 position of the imidazole ring. Some of them were more potent inhibitors of carragenan-induced edema than indomethacin. An electron spin resonance study indicated that these compounds possess anti-radical activity.

Synthesis and antithyroid activity of 1,4,5-trialkyl 2-thioimidazole derivatives

A series of compounds based on the structure of MTI (1-methyl-2-thioimidazole) were synthesized by condensation of α-hydroxyketones and alkylthioureas. The α-hydroxyketones were obtained by a radical reaction in the presence of sodium and the alkyl ester, while the alkylthioureas were prepared by nucleophilic addition of ammonia on an alkylisothiocyanate. The antithyroid activity of the 13 compounds prepared was evaluated in vitro by determination of the concentrations which led to a 50% inhibition (IC50) of the activity of thyroid peroxidase, and in vivo by assay of thyroid hormones levels and histological examination of the thyroid gland in rats treated chronically with the compounds. 1-methyl-4,5-dipropyl 2-thioimidazole (compound 10) was found to have the highest antithyroid activity of the 13 compounds synthesized.

Studies on acetylenic compounds. XXV. Ring closure. (5). New synthetic method of heterocyclic compounds from alpha-amino- and alpha-N-substituted amino- acetylenic compounds.

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