1192347-25-3

Basic information

• Product Name: (R)-1-(1-hydroxybutan-2-yl)-3-phenylthiourea
• Synonyms: (R)-1-(1-hydroxybutan-2-yl)-3-phenylthiourea
• CAS NO: 1192347-25-3
• Molecular Weight: 224.327
• Mol File: 1192347-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(1-hydroxybutan-2-yl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(1-hydroxybutan-2-yl)-3-phenylthiourea(1192347-25-3)
• EPA Substance Registry System: (R)-1-(1-hydroxybutan-2-yl)-3-phenylthiourea(1192347-25-3)

Safety Data

• Hazardous Substances Data: 1192347-25-3(Hazardous Substances Data)

Upstream product

• 5856-63-3 (2R)-2-aminobutan-1-ol 
• 103-72-0 phenyl isothiocyanate 

Relevant articles and documents

Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration

The synthesis of 47 structurally diverse compounds incorporating the (R)-2-amino-1-butanol motif has been realized. Ten of these compounds were found to exhibit in vitro specific activity against Mycobacterium tuberculosis H37Rv in a MIC range of 0.65 μM-14.03 μM. Five of the most active compounds 11, 22, 23, 31 and 42 (5.7-11.1 fold more active than ethambutol) can be outlined with very low cytotoxicity towards human embryonal kidney non-tumour cells (SI ranging from 91.2 to 375.4). For the purpose of comparison the (S)-enantiomers of these most active compounds have been synthesized and evaluated towards M. tuberculosis H37Rv showing no activity even at 20-32 fold higher concentrations.