119244-91-6Relevant articles and documents
Development of a chemoenzymatic strategy for the synthesis of optically active and orthogonally protected polyamines
Busto, Eduardo,Gotor-Fernández, Vicente,Montejo-Bernardo, Jose,García-Granda, Santiago,Gotor, Vicente
, p. 8393 - 8401 (2009)
The chemical preparation and stereoselective enzymatic desymmetrization of a series of prochiral 2-substituted-1,3-propanediamines have been carried out using Pseudomonas cepacia lipase as biocatalyst. Syntheses of novel optically active orthogonally protected di- or triamines have been achieved for the first time with different grade of enantiodiscrimination depending on the C-2 substitution of the propane-1,3-diamine fragment. Final monoselective deprotection reactions of (S)-3-allyl-2-tert-butyl-1-(9-fluorenylmethyl)propane-1,2,3-triyltriscarbamate have allowed us to obtain a panel of novel enantiomerically enriched disubstituted triamines, compounds of difficult access by conventional synthetic methods.
A General Route to the Synthesis of N-Protected 1-Substituted and 1,2-Disubstituted Taurines
Xu, Jiaxi,Xu, Shu
, p. 276 - 282 (2007/10/03)
N-Benzyloxycarbonyl protected α-substituted and αβ- disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of α-substituted and α,β- disubstituted β-sulfonopeptides.
