1192603-75-0Relevant articles and documents
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1- phenylpyrrolidine derivatives as novel androgen receptor antagonists
Yamamoto, Satoshi,Kobayashi, Hiromi,Kaku, Tomohiro,Aikawa, Katsuji,Hara, Takahito,Yamaoka, Masuo,Kanzaki, Naoyuki,Hasuoka, Atsushi,Baba, Atsuo,Ito, Mitsuhiro
, p. 70 - 83 (2013/02/22)
We designed and synthesized a series of 3-aryl-3-hydroxy-1- phenylpyrrolidine derivatives D and evaluated their potential as novel androgen receptor (AR) antagonists therapeutically effective against castration-resistant prostate cancer (CRPC). Introducti