1193487-32-9

Basic information

• Product Name: 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide
• Synonyms: 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide
• CAS NO: 1193487-32-9
• Molecular Weight: 436.281
• Mol File: 1193487-32-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide(1193487-32-9)
• EPA Substance Registry System: 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid cyclopropyl-methoxy-amide(1193487-32-9)

Safety Data

• Hazardous Substances Data: 1193487-32-9(Hazardous Substances Data)

Upstream product

• 1193487-31-8 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 75647-90-4 O-cyclopropylmethyl-hydroxylamine 
• 1193488-44-6 5-oxo-7-trifluoromethanesulfonyloxy-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 72130-68-8 ethyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-8-indolizinecarboxylate 
• 1193487-30-7 7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 

Relevant articles and documents

MEK INHIBITOR SALTS AND SOLVATES THEREOF

The present invention relates to sodium salt forms of 7-(4-Bromo-2-fluoro- phenylamino)-6-methyl-5-oxo-1,3,5-tetrahydro-indolizine-8-carboxylic acid (2- hydroxyethoxy)-amide and 7-(4-Bromo-2-fluoro-phenylamino)-5-oxo- 1,2,3,5-tetrahydro- indolizine-8-carboxylic acid cyclopropylmethoxy-amide and their corresponding solvates and polymorphs, which are useful in the treatment of a disease, disorder or syndrome associated with MEK inhibition, such as cancer, in mammals.