1193488-35-5

Basic information

• Product Name: 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide
• Synonyms: 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide
• CAS NO: 1193488-35-5
• Molecular Weight: 466.307
• Mol File: 1193488-35-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide(1193488-35-5)
• EPA Substance Registry System: 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide(1193488-35-5)

Safety Data

• Hazardous Substances Data: 1193488-35-5(Hazardous Substances Data)

Upstream product

• 1193488-47-9 6-methyl 5-oxo-7-trifluoromethanesulfonyloxy-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 1193487-42-1 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 72130-68-8 ethyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-8-indolizinecarboxylate 
• 1150098-36-4 7-chloro-6-methyl-5-oxo-1,2,3, 5-tetrahydro-indolizine-8-carboxylic acid 
• 1150098-35-3 7-chloro-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 116993-42-1 7-Hydroxy-8-(ethoxycarbonyl)-6-methyl-2,3-dihydro-1H-indolizin-5-one 
• 391212-29-6 O-(2-vinyloxyethyl)hydroxylamine 
• 1193487-43-2 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 

Downstream Products

• 1150098-45-5 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,3,5,1-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide 

Relevant articles and documents

MEK INHIBITOR SALTS AND SOLVATES THEREOF

The present invention relates to sodium salt forms of 7-(4-Bromo-2-fluoro- phenylamino)-6-methyl-5-oxo-1,3,5-tetrahydro-indolizine-8-carboxylic acid (2- hydroxyethoxy)-amide and 7-(4-Bromo-2-fluoro-phenylamino)-5-oxo- 1,2,3,5-tetrahydro- indolizine-8-carboxylic acid cyclopropylmethoxy-amide and their corresponding solvates and polymorphs, which are useful in the treatment of a disease, disorder or syndrome associated with MEK inhibition, such as cancer, in mammals.

Heterocyclic Compounds as MEK Inhibitors

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.