1193686-48-4Relevant articles and documents
In situ generation and trapping of aryllithium and arylpotassium species by halogen, sulfur, and carbon electrophiles
Popov, Ilya,Do, Hien-Quang,Daugulis, Olafs
supporting information; experimental part, p. 8309 - 8313 (2010/01/16)
(Chemical Equation Presented) A general method has been developed for in situ trapping of arylmetal intermediates by halogen, sulfur, ketone, and aldehyde electrophiles affording the functionalization of the most acidic position in arene. Pentafluorobenzene, benzothiazole, and benzoxazole can be functionalized by using K3PO4 base. For less acidic arenes, tBuOLi base is required. Arenes with DMSO pKa values of 35 or less are reactive. 2009 American Chemical Society.